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Odds and predictions as of
Friday, September 26, 2025
6:21 PM
MLB
FINALFri 26 Sep · 18:21
This event has concluded
Final score: Chicago Cubs 12 – 1 St. Louis Cardinals
Looking for upcoming predictions? Check out the latest picks below.
Chicago Cubs vs St. Louis Cardinals prediction & analysis
The Cubs are strong favorites with odds of 1.61, implying a 62% win probability. The significant gap between the teams' odds suggests the market has identified clear advantages for Chicago, likely factoring in their home field advantage at Wrigley Field along with their generally stronger recent form compared to their division rivals. While Cardinals-Cubs matchups often produce surprises given their historic rivalry, the odds movement and market confidence points to a Cubs victory. Always bet responsibly and never wager more than you can afford to lose.
AI analysis by The Diamond Edge · 75% confidence · Read the full prediction
AI model output for informational purposes only — not betting advice. Please gamble responsibly. 18+.
AI Predictions for Chicago Cubs vs St. Louis Cardinals
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Event History: Chicago Cubs vs St. Louis Cardinals
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Frequently Asked Questions: Chicago Cubs vs St. Louis Cardinals
Who will win Chicago Cubs vs St. Louis Cardinals?
Our highest-confidence AI model picks Chicago Cubs to win (75% confidence). See the AI Predictions section for the full model lineup and reasoning. Always bet responsibly.
What is the AI prediction for Chicago Cubs vs St. Louis Cardinals?
We have 1 AI prediction for this match from The Diamond Edge. Each prediction includes confidence ratings and expected value analysis — see the AI Predictions section above for picks and reasoning.
What league is Chicago Cubs vs St. Louis Cardinals in?
This match is part of MLB. You can find more MLB predictions and odds on our league page.
What are the best odds for Chicago Cubs vs St. Louis Cardinals?
We track live odds from multiple bookmakers for this match. Check our Betting Odds section above to compare prices, find the best value, and spot any line movements before kickoff.