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See the AI verdict, the final result and how the odds moved for this MLB match.
Odds as of
Compare MLB betting odds for Cleveland Guardians vs Houston Astros across all markets — moneyline, spreads, totals and more, aggregated from the sportsbooks below.
This MLB fixture kicks off Apr 22, 2026. Compare live Cleveland Guardians vs Houston Astros odds aggregated from $80+ bookmakers, refreshed every few minutes. Best-price highlighting flags the sharpest number on each market so you can see at a glance where the value sits — moneyline, spread, totals and more — without opening a dozen tabs.
Odds alone only tell you the market's price. Pair them with the AI prediction for this match — each pick ships with a confidence rating and a public win/loss history — to judge whether a line is actually worth taking.