About Los Angeles Rams vs Indianapolis Colts odds

This NFL fixture kicks off Sep 28, 2025. Compare live Los Angeles Rams vs Indianapolis Colts odds aggregated from $80+ bookmakers, refreshed every few minutes. Best-price highlighting flags the sharpest number on each market so you can see at a glance where the value sits — moneyline, spread, totals and more — without opening a dozen tabs.

Odds alone only tell you the market's price. Pair them with the AI prediction for this match — each pick ships with a confidence rating and a public win/loss history — to judge whether a line is actually worth taking.