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See the AI verdict, the final result and how the odds moved for this NFL match.
Odds as of
Compare NFL betting odds for Indianapolis Colts vs San Francisco 49ers across all markets — moneyline, spreads, totals and more, aggregated from the sportsbooks below.
This NFL fixture kicks off Dec 23, 2025. Compare live Indianapolis Colts vs San Francisco 49ers odds aggregated from $80+ bookmakers, refreshed every few minutes. Best-price highlighting flags the sharpest number on each market so you can see at a glance where the value sits — moneyline, spread, totals and more — without opening a dozen tabs.
Odds alone only tell you the market's price. Pair them with the AI prediction for this match — each pick ships with a confidence rating and a public win/loss history — to judge whether a line is actually worth taking.