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Odds as of
Compare NFL betting odds for San Francisco 49ers vs Jacksonville Jaguars across all markets — moneyline, spreads, totals and more, aggregated from the sportsbooks below.
This NFL fixture kicks off Sep 28, 2025. Compare live San Francisco 49ers vs Jacksonville Jaguars odds aggregated from $80+ bookmakers, refreshed every few minutes. Best-price highlighting flags the sharpest number on each market so you can see at a glance where the value sits — moneyline, spread, totals and more — without opening a dozen tabs.
Odds alone only tell you the market's price. Pair them with the AI prediction for this match — each pick ships with a confidence rating and a public win/loss history — to judge whether a line is actually worth taking.
See the AI verdict, the final result and how the odds moved for this NFL match.